Vidalista 40, which contains the active ingredient tadalafil, primarily targets phosphodiesterase type 5 (PDE5) receptors in the body. These receptors are found mainly in the smooth muscle cells of the corpus cavernosum of the penis, as well as in blood vessels in other tissues such as the lungs and vascular smooth muscle. By inhibiting PDE5, tadalafil prevents the breakdown of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels lead to smooth muscle relaxation, increased blood flow, and improved erectile response during sexual stimulation. Indirectly, Vidalista 40 mg also influences nitric oxide (NO) signaling pathways, since NO activates the production of cGMP. While its main therapeutic action is through PDE5 inhibition, tadalafil has mild effects on PDE11 receptors, which are located in skeletal muscle and other tissues, but these effects are not fully understood and may contribute to some side effects like muscle aches. Thus, Vidalista 40’s key target is PDE5 receptors, making it effective in treating erectile dysfunction and certain cases of pulmonary arterial hypertension.
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